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Schoenfeld JD, Sibenaller ZA, Mapuskar KA et al (2017) O2- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate

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Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

Journal of Medicinal Food

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